Lipid peroxidation is the one of the common part in the oxidative stress of diabetes, which is found in about 40% of diabetics. In the present study, anti-oxidative stress efficacy of Mitrgyna Parvifolia was evaluated in streptozotocin (STZ)-induced diabetic rats. The effect of oral administration of ethanolic extract of Mitrgyna Parvifolia leaves (50,100, 150 mg/kg body weight) were examined on the levels of malondialdehyde (lipid peroxidation) in liver and kidney tissues of STZ (90 mg/kg body weight in rat pups) induced diabetic rats. STZ-induced diabetic rats, showed significant increase in the levels of malondialdehyde, which were considerably restored to near normal in Mitrgyna Parvifolia leaves ethanolic extract (95%) treated animals groups. It may be concluded that, Mitrgyna Parvifolia leaves possesses anti-oxidative stress effect, which may be due to the presence of alkaloids, flavonoids, saponins, glycosides and triterpenoids in the extract.
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